Pantothenate kinase 3 (PANK3)
Homo sapiens — UniProt Q9H999
Data last refreshed: (UniProt release unknown)
Key facts
Pantothenate kinase 3 (PANK3) is a protein from Homo sapiens identified by UniProt accession Q9H999, 370 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9H999; gene symbol PANK3.
- Organism: Homo sapiens.
- Length: 370 amino acids.
- Top disease associations (Open Targets): Parkinson disease, lysosomal storage disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pantothenate kinase 3 |
|---|---|
| UniProt accession | Q9H999 |
| Gene | PANK3 |
| Organism | Homo sapiens |
| Length | 370 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.33
- lysosomal storage disease · score 0.33
- multiple sclerosis · score 0.33
- neurodegenerative disease · score 0.33
- Alzheimer disease · score 0.33
- body height · score 0.08
- lean body mass · score 0.07
- diastolic blood pressure · score 0.06
- self reported educational attainment · score 0.06
- BMI-adjusted hip circumference · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H999-F1 | alphafold | PREDICTED | 94.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H999.
Amino-acid sequence (370 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PANK3?
The strongest Open Targets associations for PANK3 are Parkinson disease, lysosomal storage disease, multiple sclerosis, neurodegenerative disease and Alzheimer disease.
How long is the PANK3 protein?
The Homo sapiens PANK3 protein (UniProt Q9H999) is 370 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H999 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H999 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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