Histone-lysine N-methyltransferase EHMT1 (EHMT1)
Homo sapiens — UniProt Q9H9B1
Data last refreshed: (UniProt release unknown)
Key facts
Histone-lysine N-methyltransferase EHMT1 (EHMT1) is a protein from Homo sapiens identified by UniProt accession Q9H9B1, 1298 residues long. MolForge cross-references it against 3 known binders and 153 disease associations.
- UniProt accession: Q9H9B1; gene symbol EHMT1.
- Organism: Homo sapiens.
- Length: 1298 amino acids.
- Top disease associations (Open Targets): Kleefstra syndrome 1, Kleefstra syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone-lysine N-methyltransferase EHMT1 |
|---|---|
| UniProt accession | Q9H9B1 |
| Gene | EHMT1 |
| Organism | Homo sapiens |
| Length | 1298 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (153)
Diseases linked to this target (Open Targets).
- Kleefstra syndrome 1 · score 0.71
- Kleefstra syndrome · score 0.70
- genetic disorder · score 0.54
- Intellectual disability · score 0.50
- Global developmental delay · score 0.41
- Kleefstra syndrome due to 9q34 microdeletion · score 0.37
- Kleefstra syndrome due to a point mutation · score 0.37
- autism spectrum disorder · score 0.36
- atopic eczema · score 0.34
- Difficulty walking · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9B1-F1 | alphafold | PREDICTED | 63.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9B1.
Amino-acid sequence (1298 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EHMT1?
The strongest Open Targets associations for EHMT1 are Kleefstra syndrome 1, Kleefstra syndrome, genetic disorder, Intellectual disability and Global developmental delay.
How long is the EHMT1 protein?
The Homo sapiens EHMT1 protein (UniProt Q9H9B1) is 1298 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9B1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9B1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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