Sideroflexin-1 (SFXN1)
Homo sapiens — UniProt Q9H9B4
Data last refreshed: (UniProt release unknown)
Key facts
Sideroflexin-1 (SFXN1) is a protein from Homo sapiens identified by UniProt accession Q9H9B4, 322 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q9H9B4; gene symbol SFXN1.
- Organism: Homo sapiens.
- Length: 322 amino acids.
- Top disease associations (Open Targets): Myopia, age at onset and refractive error.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sideroflexin-1 |
|---|---|
| UniProt accession | Q9H9B4 |
| Gene | SFXN1 |
| Organism | Homo sapiens |
| Length | 322 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- Myopia · score 0.20
- age at onset · score 0.20
- refractive error · score 0.20
- alanine measurement · score 0.17
- protein measurement · score 0.12
- ulcerative colitis · score 0.12
- lung adenocarcinoma · score 0.10
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.07
- mathematical ability · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9B4-F1 | alphafold | PREDICTED | 86.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9B4.
Amino-acid sequence (322 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFXN1?
The strongest Open Targets associations for SFXN1 are Myopia, age at onset, refractive error, alanine measurement and protein measurement.
How long is the SFXN1 protein?
The Homo sapiens SFXN1 protein (UniProt Q9H9B4) is 322 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9B4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9B4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.