Zinc finger protein 408 (ZNF408)
Homo sapiens — UniProt Q9H9D4
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 408 (ZNF408) is a protein from Homo sapiens identified by UniProt accession Q9H9D4, 720 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9H9D4; gene symbol ZNF408.
- Organism: Homo sapiens.
- Length: 720 amino acids.
- Top disease associations (Open Targets): Familial exudative vitreoretinopathy, retinitis pigmentosa and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 408 |
|---|---|
| UniProt accession | Q9H9D4 |
| Gene | ZNF408 |
| Organism | Homo sapiens |
| Length | 720 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- Familial exudative vitreoretinopathy · score 0.67
- retinitis pigmentosa · score 0.59
- Retinal dystrophy · score 0.39
- neurodegenerative disease · score 0.37
- autosomal recessive retinitis pigmentosa · score 0.33
- monocyte count · score 0.19
- genetic disorder · score 0.19
- femoral neck bone mineral density · score 0.10
- heel bone mineral density · score 0.08
- high density lipoprotein cholesterol measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9D4-F1 | alphafold | PREDICTED | 55.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9D4.
Amino-acid sequence (720 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF408?
The strongest Open Targets associations for ZNF408 are Familial exudative vitreoretinopathy, retinitis pigmentosa, Retinal dystrophy, neurodegenerative disease and autosomal recessive retinitis pigmentosa.
How long is the ZNF408 protein?
The Homo sapiens ZNF408 protein (UniProt Q9H9D4) is 720 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9D4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9D4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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