Conserved oligomeric Golgi complex subunit 4 (COG4)
Homo sapiens — UniProt Q9H9E3
Data last refreshed: (UniProt release unknown)
Key facts
Conserved oligomeric Golgi complex subunit 4 (COG4) is a protein from Homo sapiens identified by UniProt accession Q9H9E3, 785 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9H9E3; gene symbol COG4.
- Organism: Homo sapiens.
- Length: 785 amino acids.
- Top disease associations (Open Targets): microcephalic osteodysplastic dysplasia, Saul-Wilson type, COG4-congenital disorder of glycosylation and congenital disorder of glycosylation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 4 |
|---|---|
| UniProt accession | Q9H9E3 |
| Gene | COG4 |
| Organism | Homo sapiens |
| Length | 785 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- microcephalic osteodysplastic dysplasia, Saul-Wilson type · score 0.79
- COG4-congenital disorder of glycosylation · score 0.78
- congenital disorder of glycosylation · score 0.54
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.38
- Delayed gross motor development · score 0.34
- alkaline phosphatase measurement · score 0.19
- Global developmental delay · score 0.12
- breast adenocarcinoma · score 0.10
- Gorham-Stout disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9E3-F1 | alphafold | PREDICTED | 84.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9E3.
Amino-acid sequence (785 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COG4?
The strongest Open Targets associations for COG4 are microcephalic osteodysplastic dysplasia, Saul-Wilson type, COG4-congenital disorder of glycosylation, congenital disorder of glycosylation, genetic disorder and neurodegenerative disease.
How long is the COG4 protein?
The Homo sapiens COG4 protein (UniProt Q9H9E3) is 785 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9E3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9E3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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