Protein argonaute-3 (AGO3)
Homo sapiens — UniProt Q9H9G7
Data last refreshed: (UniProt release unknown)
Key facts
Protein argonaute-3 (AGO3) is a protein from Homo sapiens identified by UniProt accession Q9H9G7, 860 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9H9G7; gene symbol AGO3.
- Organism: Homo sapiens.
- Length: 860 amino acids.
- Top disease associations (Open Targets): cancer, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein argonaute-3 |
|---|---|
| UniProt accession | Q9H9G7 |
| Gene | AGO3 |
| Organism | Homo sapiens |
| Length | 860 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- cancer · score 0.46
- glioblastoma multiforme · score 0.29
- breast adenocarcinoma · score 0.29
- endometrial cancer · score 0.28
- head and neck squamous cell carcinoma · score 0.27
- lung adenocarcinoma · score 0.27
- squamous cell lung carcinoma · score 0.26
- gastric adenocarcinoma · score 0.24
- appendicular lean mass · score 0.19
- urinary bladder cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9G7-F1 | alphafold | PREDICTED | 91.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9G7.
Amino-acid sequence (860 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGO3?
The strongest Open Targets associations for AGO3 are cancer, glioblastoma multiforme, breast adenocarcinoma, endometrial cancer and head and neck squamous cell carcinoma.
How long is the AGO3 protein?
The Homo sapiens AGO3 protein (UniProt Q9H9G7) is 860 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9G7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9G7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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