Vacuolar protein sorting-associated protein 37B (VPS37B)
Homo sapiens — UniProt Q9H9H4
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 37B (VPS37B) is a protein from Homo sapiens identified by UniProt accession Q9H9H4, 285 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9H9H4; gene symbol VPS37B.
- Organism: Homo sapiens.
- Length: 285 amino acids.
- Top disease associations (Open Targets): HIV infection, viral disease and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 37B |
|---|---|
| UniProt accession | Q9H9H4 |
| Gene | VPS37B |
| Organism | Homo sapiens |
| Length | 285 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.53
- viral disease · score 0.46
- neurodegenerative disease · score 0.27
- Red cell distribution width · score 0.10
- HbA1c measurement · score 0.08
- schizophrenia · score 0.06
- apolipoprotein A 1 measurement · score 0.06
- atrial fibrillation · score 0.06
- high density lipoprotein cholesterol measurement · score 0.05
- congenital enteropathy due to enteropeptidase deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9H4-F1 | alphafold | PREDICTED | 75.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9H4.
Amino-acid sequence (285 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS37B?
The strongest Open Targets associations for VPS37B are HIV infection, viral disease, neurodegenerative disease, Red cell distribution width and HbA1c measurement.
How long is the VPS37B protein?
The Homo sapiens VPS37B protein (UniProt Q9H9H4) is 285 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9H4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9H4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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