Large ribosomal subunit protein mL44 (MRPL44)
Homo sapiens — UniProt Q9H9J2
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein mL44 (MRPL44) is a protein from Homo sapiens identified by UniProt accession Q9H9J2, 332 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9H9J2; gene symbol MRPL44.
- Organism: Homo sapiens.
- Length: 332 amino acids.
- Top disease associations (Open Targets): infantile hypertrophic cardiomyopathy due to MRPL44 deficiency, mitochondrial disease and Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein mL44 |
|---|---|
| UniProt accession | Q9H9J2 |
| Gene | MRPL44 |
| Organism | Homo sapiens |
| Length | 332 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- infantile hypertrophic cardiomyopathy due to MRPL44 deficiency · score 0.65
- mitochondrial disease · score 0.37
- Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 · score 0.34
- hepatoencephalopathy due to combined oxidative phosphorylation defect type 1 · score 0.34
- neurodegenerative disease · score 0.24
- genetic disorder · score 0.19
- platelet-derived growth factor BB measurement · score 0.08
- BMI-adjusted waist circumference · score 0.06
- body height · score 0.06
- papillary thyroid carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9J2-F1 | alphafold | PREDICTED | 88.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9J2.
Amino-acid sequence (332 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL44?
The strongest Open Targets associations for MRPL44 are infantile hypertrophic cardiomyopathy due to MRPL44 deficiency, mitochondrial disease, Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1, hepatoencephalopathy due to combined oxidative phosphorylation defect type 1 and neurodegenerative disease.
How long is the MRPL44 protein?
The Homo sapiens MRPL44 protein (UniProt Q9H9J2) is 332 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9J2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9J2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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