Ubiquitin carboxyl-terminal hydrolase 42 (USP42)
Homo sapiens — UniProt Q9H9J4
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 42 (USP42) is a protein from Homo sapiens identified by UniProt accession Q9H9J4, 1324 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9H9J4; gene symbol USP42.
- Organism: Homo sapiens.
- Length: 1324 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 42 |
|---|---|
| UniProt accession | Q9H9J4 |
| Gene | USP42 |
| Organism | Homo sapiens |
| Length | 1324 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- neoplasm · score 0.05
- gonorrhea · score 0.05
- platelet count · score 0.05
- azoospermia · score 0.05
- hypergonadotropic hypogonadism-cataract syndrome · score 0.04
- Hypergonadotropic hypogonadism - cataract syndrome · score 0.04
- partial chromosome Y deletion · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9J4-F1 | alphafold | PREDICTED | 48.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9J4.
Amino-acid sequence (1324 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP42?
The strongest Open Targets associations for USP42 are neurodegenerative disease, glioblastoma multiforme, breast adenocarcinoma, neoplasm and gonorrhea.
How long is the USP42 protein?
The Homo sapiens USP42 protein (UniProt Q9H9J4) is 1324 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9J4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9J4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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