Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2)
Homo sapiens — UniProt Q9H9L3
Data last refreshed: (UniProt release unknown)
Key facts
Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2) is a protein from Homo sapiens identified by UniProt accession Q9H9L3, 353 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9H9L3; gene symbol ISG20L2.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, Red cell distribution width and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interferon-stimulated 20 kDa exonuclease-like 2 |
|---|---|
| UniProt accession | Q9H9L3 |
| Gene | ISG20L2 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.14
- Red cell distribution width · score 0.13
- high density lipoprotein cholesterol measurement · score 0.13
- bilirubin measurement · score 0.13
- total blood protein measurement · score 0.13
- platelet count · score 0.09
- body height · score 0.09
- blood protein measurement · score 0.08
- Miyoshi myopathy · score 0.07
- platelet crit · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9L3-F1 | alphafold | PREDICTED | 72.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9L3.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ISG20L2?
The strongest Open Targets associations for ISG20L2 are sex hormone-binding globulin measurement, Red cell distribution width, high density lipoprotein cholesterol measurement, bilirubin measurement and total blood protein measurement.
How long is the ISG20L2 protein?
The Homo sapiens ISG20L2 protein (UniProt Q9H9L3) is 353 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9L3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9L3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.