Putative E3 ubiquitin-protein ligase UNKL (UNKL)
Homo sapiens — UniProt Q9H9P5
Data last refreshed: (UniProt release unknown)
Key facts
Putative E3 ubiquitin-protein ligase UNKL (UNKL) is a protein from Homo sapiens identified by UniProt accession Q9H9P5, 680 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q9H9P5; gene symbol UNKL.
- Organism: Homo sapiens.
- Length: 680 amino acids.
- Top disease associations (Open Targets): body height, blood protein measurement and inflammatory biomarker measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Putative E3 ubiquitin-protein ligase UNKL |
|---|---|
| UniProt accession | Q9H9P5 |
| Gene | UNKL |
| Organism | Homo sapiens |
| Length | 680 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- body height · score 0.28
- blood protein measurement · score 0.23
- inflammatory biomarker measurement · score 0.20
- YKL40 measurement · score 0.20
- clear cell renal carcinoma · score 0.18
- GNPTG-mucolipidosis · score 0.17
- lean body mass · score 0.06
- deafness · score 0.05
- juvenile dermatomyositis · score 0.01
- COVID-19 · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9P5-F1 | alphafold | PREDICTED | 65.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9P5.
Amino-acid sequence (680 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNKL?
The strongest Open Targets associations for UNKL are body height, blood protein measurement, inflammatory biomarker measurement, YKL40 measurement and clear cell renal carcinoma.
How long is the UNKL protein?
The Homo sapiens UNKL protein (UniProt Q9H9P5) is 680 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9P5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9P5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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