L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH)
Homo sapiens — UniProt Q9H9P8
Data last refreshed: (UniProt release unknown)
Key facts
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) is a protein from Homo sapiens identified by UniProt accession Q9H9P8, 463 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9H9P8; gene symbol L2HGDH.
- Organism: Homo sapiens.
- Length: 463 amino acids.
- Top disease associations (Open Targets): L-2-hydroxyglutaric aciduria, neurodegenerative disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | L-2-hydroxyglutarate dehydrogenase, mitochondrial |
|---|---|
| UniProt accession | Q9H9P8 |
| Gene | L2HGDH |
| Organism | Homo sapiens |
| Length | 463 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- L-2-hydroxyglutaric aciduria · score 0.83
- neurodegenerative disease · score 0.51
- lysosomal storage disease · score 0.37
- mitochondrial disease · score 0.37
- serum metabolite measurement · score 0.30
- Abnormality of metabolism/homeostasis · score 0.27
- bilirubin measurement · score 0.26
- aspartate aminotransferase measurement · score 0.24
- sex hormone-binding globulin measurement · score 0.22
- serum alanine aminotransferase measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9P8-F1 | alphafold | PREDICTED | 87.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9P8.
Amino-acid sequence (463 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with L2HGDH?
The strongest Open Targets associations for L2HGDH are L-2-hydroxyglutaric aciduria, neurodegenerative disease, lysosomal storage disease, mitochondrial disease and serum metabolite measurement.
How long is the L2HGDH protein?
The Homo sapiens L2HGDH protein (UniProt Q9H9P8) is 463 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9P8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9P8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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