Non-homologous end-joining factor 1 (NHEJ1)
Homo sapiens — UniProt Q9H9Q4
Data last refreshed: (UniProt release unknown)
Key facts
Non-homologous end-joining factor 1 (NHEJ1) is a protein from Homo sapiens identified by UniProt accession Q9H9Q4, 299 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.
- UniProt accession: Q9H9Q4; gene symbol NHEJ1.
- Organism: Homo sapiens.
- Length: 299 amino acids.
- Top disease associations (Open Targets): Cernunnos-XLF deficiency, combined immunodeficiency and Combined immunodeficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Non-homologous end-joining factor 1 |
|---|---|
| UniProt accession | Q9H9Q4 |
| Gene | NHEJ1 |
| Organism | Homo sapiens |
| Length | 299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (171)
Diseases linked to this target (Open Targets).
- Cernunnos-XLF deficiency · score 0.78
- combined immunodeficiency · score 0.37
- Combined immunodeficiency · score 0.37
- T-B+ severe combined immunodeficiency · score 0.37
- T-B- severe combined immunodeficiency · score 0.37
- syndactyly type 1 · score 0.33
- isolated anophthalmia-microphthalmia syndrome · score 0.27
- body height · score 0.24
- breast adenocarcinoma · score 0.23
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9Q4-F1 | alphafold | PREDICTED | 81.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9Q4.
Amino-acid sequence (299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NHEJ1?
The strongest Open Targets associations for NHEJ1 are Cernunnos-XLF deficiency, combined immunodeficiency, Combined immunodeficiency, T-B+ severe combined immunodeficiency and T-B- severe combined immunodeficiency.
How long is the NHEJ1 protein?
The Homo sapiens NHEJ1 protein (UniProt Q9H9Q4) is 299 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9Q4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9Q4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.