Homeobox protein NANOG (NANOG)
Homo sapiens — UniProt Q9H9S0
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein NANOG (NANOG) is a protein from Homo sapiens identified by UniProt accession Q9H9S0, 305 residues long. MolForge cross-references it against 0 known binders and 346 disease associations.
- UniProt accession: Q9H9S0; gene symbol NANOG.
- Organism: Homo sapiens.
- Length: 305 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein NANOG |
|---|---|
| UniProt accession | Q9H9S0 |
| Gene | NANOG |
| Organism | Homo sapiens |
| Length | 305 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (346)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- head and neck squamous cell carcinoma · score 0.21
- glioblastoma multiforme · score 0.20
- cutaneous melanoma · score 0.15
- neoplasm · score 0.12
- oral squamous cell carcinoma · score 0.11
- hepatocellular carcinoma · score 0.11
- cancer · score 0.11
- lung adenocarcinoma · score 0.10
- esophageal squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9S0-F1 | alphafold | PREDICTED | 57.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9S0.
Amino-acid sequence (305 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NANOG?
The strongest Open Targets associations for NANOG are neurodegenerative disease, head and neck squamous cell carcinoma, glioblastoma multiforme, cutaneous melanoma and neoplasm.
How long is the NANOG protein?
The Homo sapiens NANOG protein (UniProt Q9H9S0) is 305 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9S0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9S0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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