Protein transport protein Sec61 subunit alpha isoform 2 (SEC61A2)
Homo sapiens — UniProt Q9H9S3
Data last refreshed: (UniProt release unknown)
Key facts
Protein transport protein Sec61 subunit alpha isoform 2 (SEC61A2) is a protein from Homo sapiens identified by UniProt accession Q9H9S3, 476 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9H9S3; gene symbol SEC61A2.
- Organism: Homo sapiens.
- Length: 476 amino acids.
- Top disease associations (Open Targets): protein measurement, type 2 diabetes mellitus and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein transport protein Sec61 subunit alpha isoform 2 |
|---|---|
| UniProt accession | Q9H9S3 |
| Gene | SEC61A2 |
| Organism | Homo sapiens |
| Length | 476 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.34
- type 2 diabetes mellitus · score 0.31
- body height · score 0.26
- prostate carcinoma · score 0.23
- diabetes mellitus · score 0.18
- glucose measurement · score 0.17
- electrocardiography · score 0.15
- HbA1c measurement · score 0.15
- Drugs used in diabetes use measurement · score 0.15
- hemoglobin A1 measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9S3-F1 | alphafold | PREDICTED | 72.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9S3.
Amino-acid sequence (476 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEC61A2?
The strongest Open Targets associations for SEC61A2 are protein measurement, type 2 diabetes mellitus, body height, prostate carcinoma and diabetes mellitus.
How long is the SEC61A2 protein?
The Homo sapiens SEC61A2 protein (UniProt Q9H9S3) is 476 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9S3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9S3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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