Ribitol 5-phosphate transferase FKRP (FKRP)
Homo sapiens — UniProt Q9H9S5
Data last refreshed: (UniProt release unknown)
Key facts
Ribitol 5-phosphate transferase FKRP (FKRP) is a protein from Homo sapiens identified by UniProt accession Q9H9S5, 495 residues long. MolForge cross-references it against 0 known binders and 293 disease associations.
- UniProt accession: Q9H9S5; gene symbol FKRP.
- Organism: Homo sapiens.
- Length: 495 amino acids.
- Top disease associations (Open Targets): autosomal recessive limb-girdle muscular dystrophy type 2I, muscular dystrophy-dystroglycanopathy type B5 and muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribitol 5-phosphate transferase FKRP |
|---|---|
| UniProt accession | Q9H9S5 |
| Gene | FKRP |
| Organism | Homo sapiens |
| Length | 495 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (293)
Diseases linked to this target (Open Targets).
- autosomal recessive limb-girdle muscular dystrophy type 2I · score 0.84
- muscular dystrophy-dystroglycanopathy type B5 · score 0.81
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5 · score 0.79
- muscular dystrophy-dystroglycanopathy, type A · score 0.67
- limb-girdle muscular dystrophy · score 0.67
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 · score 0.54
- Abnormality of the cardiovascular system · score 0.54
- autosomal recessive limb-girdle muscular dystrophy · score 0.53
- neurodegenerative disease · score 0.49
- myopathy caused by variation in FKRP · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9S5-F1 | alphafold | PREDICTED | 93.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9S5.
Amino-acid sequence (495 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FKRP?
The strongest Open Targets associations for FKRP are autosomal recessive limb-girdle muscular dystrophy type 2I, muscular dystrophy-dystroglycanopathy type B5, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5, muscular dystrophy-dystroglycanopathy, type A and limb-girdle muscular dystrophy.
How long is the FKRP protein?
The Homo sapiens FKRP protein (UniProt Q9H9S5) is 495 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9S5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9S5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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