GPN-loop GTPase 2 (GPN2)
Homo sapiens — UniProt Q9H9Y4
Data last refreshed: (UniProt release unknown)
Key facts
GPN-loop GTPase 2 (GPN2) is a protein from Homo sapiens identified by UniProt accession Q9H9Y4, 310 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9H9Y4; gene symbol GPN2.
- Organism: Homo sapiens.
- Length: 310 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, total blood protein measurement and serum gamma-glutamyl transferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPN-loop GTPase 2 |
|---|---|
| UniProt accession | Q9H9Y4 |
| Gene | GPN2 |
| Organism | Homo sapiens |
| Length | 310 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- total blood protein measurement · score 0.14
- serum gamma-glutamyl transferase measurement · score 0.12
- IGF-1 measurement · score 0.07
- eosinophil count · score 0.05
- hair color · score 0.05
- monocyte count · score 0.05
- cardiovascular disease · score 0.05
- myeloid white cell count · score 0.05
- monocyte percentage of leukocytes · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9Y4-F1 | alphafold | PREDICTED | 84.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9Y4.
Amino-acid sequence (310 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPN2?
The strongest Open Targets associations for GPN2 are neurodegenerative disease, total blood protein measurement, serum gamma-glutamyl transferase measurement, IGF-1 measurement and eosinophil count.
How long is the GPN2 protein?
The Homo sapiens GPN2 protein (UniProt Q9H9Y4) is 310 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9Y4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9Y4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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