DNA-directed RNA polymerase I subunit RPA2 (POLR1B)
Homo sapiens — UniProt Q9H9Y6
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase I subunit RPA2 (POLR1B) is a protein from Homo sapiens identified by UniProt accession Q9H9Y6, 1135 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9H9Y6; gene symbol POLR1B.
- Organism: Homo sapiens.
- Length: 1135 amino acids.
- Top disease associations (Open Targets): Treacher Collins syndrome 4, Treacher-Collins syndrome and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase I subunit RPA2 |
|---|---|
| UniProt accession | Q9H9Y6 |
| Gene | POLR1B |
| Organism | Homo sapiens |
| Length | 1135 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- Treacher Collins syndrome 4 · score 0.72
- Treacher-Collins syndrome · score 0.38
- endometrial cancer · score 0.24
- C-reactive protein measurement · score 0.19
- smoking behavior · score 0.17
- breast adenocarcinoma · score 0.11
- smoking status measurement · score 0.09
- Hypomaturation amelogenesis imperfecta · score 0.06
- non-small cell lung carcinoma · score 0.05
- Hypoplastic amelogenesis imperfecta · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9Y6-F1 | alphafold | PREDICTED | 92.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9Y6.
Amino-acid sequence (1135 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR1B?
The strongest Open Targets associations for POLR1B are Treacher Collins syndrome 4, Treacher-Collins syndrome, endometrial cancer, C-reactive protein measurement and smoking behavior.
How long is the POLR1B protein?
The Homo sapiens POLR1B protein (UniProt Q9H9Y6) is 1135 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9Y6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9Y6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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