Protein lin-28 homolog A (LIN28A)
Homo sapiens — UniProt Q9H9Z2
Data last refreshed: (UniProt release unknown)
Key facts
Protein lin-28 homolog A (LIN28A) is a protein from Homo sapiens identified by UniProt accession Q9H9Z2, 209 residues long. MolForge cross-references it against 0 known binders and 322 disease associations.
- UniProt accession: Q9H9Z2; gene symbol LIN28A.
- Organism: Homo sapiens.
- Length: 209 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein lin-28 homolog A |
|---|---|
| UniProt accession | Q9H9Z2 |
| Gene | LIN28A |
| Organism | Homo sapiens |
| Length | 209 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (322)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.57
- lysosomal storage disease · score 0.35
- body height · score 0.32
- appendicular lean mass · score 0.27
- forced expiratory volume · score 0.27
- sitting height measurement · score 0.25
- neoplasm · score 0.11
- cancer · score 0.10
- peak expiratory flow · score 0.09
- acute myeloid leukemia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H9Z2-F1 | alphafold | PREDICTED | 76.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H9Z2.
Amino-acid sequence (209 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIN28A?
The strongest Open Targets associations for LIN28A are neurodegenerative disease, lysosomal storage disease, body height, appendicular lean mass and forced expiratory volume.
How long is the LIN28A protein?
The Homo sapiens LIN28A protein (UniProt Q9H9Z2) is 209 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H9Z2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H9Z2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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