TLR adapter interacting with SLC15A4 on the…

About TLR adapter interacting with SLC15A4 on the lysosome

TLR adapter interacting with SLC15A4 on the lysosome (TASL) is a protein from Homo sapiens identified by UniProt accession Q9HAI6, 301 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	TLR adapter interacting with SLC15A4 on the lysosome
UniProt accession	Q9HAI6
Gene	TASL
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

Systemic lupus erythematosus · score 0.08
cancer · score 0.07
neoplasm · score 0.07
lung adenocarcinoma · score 0.07
glioblastoma multiforme · score 0.03
ulcerative colitis · score 0.01
renal cell carcinoma · score 0.01
oligoastrocytoma · score 0.01
cutaneous lupus erythematosus · score 0.01
bladder transitional cell carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HAI6-F1	alphafold	PREDICTED	58.32	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HAI6.

Amino-acid sequence (301 residues)

MLSEGYLSGL EYWNDIHWSC ASYNEQVAGE KEEETNSVAT LSYSSVDETQ VRSLYVSCKS SGKFISSVHS RESQHSRSQR VTVLQTNPNP VFESPNLAAV EICRDASRET YLVPSSCKSI CKNYNDLQIA GGQVMAINSV TTDFPSESSF EYGPLLKSSE IPLPMEDSIS TQPSDFPQKP IQRYSSYWRI TSIKEKSSLQ MQNPISNAVL NEYLEQKVVE LYKQYIMDTV FHDSSPTQIL ASELIMTSVD QISLQVSREK NLETSKARDI VFSRLLQLMS TEITEISTPS LHISQYSNVN P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

TLR adapter interacting with SLC15A4 on the lysosome (TASL)