Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1)
Homo sapiens — UniProt Q9HAN9
Data last refreshed: (UniProt release unknown)
Key facts
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) is a protein from Homo sapiens identified by UniProt accession Q9HAN9, 279 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.
- UniProt accession: Q9HAN9; gene symbol NMNAT1.
- Organism: Homo sapiens.
- Length: 279 amino acids.
- Top disease associations (Open Targets): Leber congenital amaurosis 9, Leber congenital amaurosis and spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 |
|---|---|
| UniProt accession | Q9HAN9 |
| Gene | NMNAT1 |
| Organism | Homo sapiens |
| Length | 279 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (265)
Diseases linked to this target (Open Targets).
- Leber congenital amaurosis 9 · score 0.81
- Leber congenital amaurosis · score 0.67
- spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis · score 0.58
- Retinal dystrophy · score 0.52
- Cone rod dystrophy · score 0.46
- NMNAT1-related retinopathy · score 0.37
- cone-rod dystrophy · score 0.34
- Nystagmus · score 0.26
- Global developmental delay · score 0.26
- cone dystrophy · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HAN9-F1 | alphafold | PREDICTED | 89.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HAN9.
Amino-acid sequence (279 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NMNAT1?
The strongest Open Targets associations for NMNAT1 are Leber congenital amaurosis 9, Leber congenital amaurosis, spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis, Retinal dystrophy and Cone rod dystrophy.
How long is the NMNAT1 protein?
The Homo sapiens NMNAT1 protein (UniProt Q9HAN9) is 279 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HAN9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HAN9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.