Adhesion G protein-coupled receptor L3 (ADGRL3)
Homo sapiens — UniProt Q9HAR2
Data last refreshed: (UniProt release unknown)
Key facts
Adhesion G protein-coupled receptor L3 (ADGRL3) is a protein from Homo sapiens identified by UniProt accession Q9HAR2, 1447 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.
- UniProt accession: Q9HAR2; gene symbol ADGRL3.
- Organism: Homo sapiens.
- Length: 1447 amino acids.
- Target class: GPCR.
- Top disease associations (Open Targets): self reported educational attainment, PR interval and chronotype measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adhesion G protein-coupled receptor L3 |
|---|---|
| UniProt accession | Q9HAR2 |
| Gene | ADGRL3 |
| Organism | Homo sapiens |
| Length | 1447 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | GPCR (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (109)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.48
- PR interval · score 0.36
- chronotype measurement · score 0.35
- attention deficit hyperactivity disorder · score 0.30
- Abnormality of refraction · score 0.28
- substance abuse · score 0.27
- antisocial behaviour measurement · score 0.27
- risk-taking behaviour · score 0.27
- mathematical ability · score 0.26
- age at first sexual intercourse measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HAR2-F1 | alphafold | PREDICTED | 69.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HAR2.
Amino-acid sequence (1447 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADGRL3?
The strongest Open Targets associations for ADGRL3 are self reported educational attainment, PR interval, chronotype measurement, attention deficit hyperactivity disorder and Abnormality of refraction.
How long is the ADGRL3 protein?
The Homo sapiens ADGRL3 protein (UniProt Q9HAR2) is 1447 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HAR2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HAR2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.