E3 ubiquitin-protein ligase pellino homolog 2 (PELI2)
Homo sapiens — UniProt Q9HAT8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) is a protein from Homo sapiens identified by UniProt accession Q9HAT8, 420 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q9HAT8; gene symbol PELI2.
- Organism: Homo sapiens.
- Length: 420 amino acids.
- Top disease associations (Open Targets): body height, mathematical ability and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase pellino homolog 2 |
|---|---|
| UniProt accession | Q9HAT8 |
| Gene | PELI2 |
| Organism | Homo sapiens |
| Length | 420 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- body height · score 0.43
- mathematical ability · score 0.37
- breast adenocarcinoma · score 0.10
- metabolite measurement · score 0.08
- blood protein measurement · score 0.07
- Miyoshi myopathy · score 0.04
- diet measurement · score 0.04
- immunodeficiency 89 and autoimmunity · score 0.03
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.03
- gonorrhea · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HAT8-F1 | alphafold | PREDICTED | 89.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HAT8.
Amino-acid sequence (420 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PELI2?
The strongest Open Targets associations for PELI2 are body height, mathematical ability, breast adenocarcinoma, metabolite measurement and blood protein measurement.
How long is the PELI2 protein?
The Homo sapiens PELI2 protein (UniProt Q9HAT8) is 420 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HAT8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HAT8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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