Beta,beta-carotene 15,15'-dioxygenase (BCO1)
Homo sapiens — UniProt Q9HAY6
Data last refreshed: (UniProt release unknown)
Key facts
Beta,beta-carotene 15,15'-dioxygenase (BCO1) is a protein from Homo sapiens identified by UniProt accession Q9HAY6, 547 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q9HAY6; gene symbol BCO1.
- Organism: Homo sapiens.
- Length: 547 amino acids.
- Top disease associations (Open Targets): hereditary hypercarotenemia and vitamin A deficiency, carotenoid measurement and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta,beta-carotene 15,15'-dioxygenase |
|---|---|
| UniProt accession | Q9HAY6 |
| Gene | BCO1 |
| Organism | Homo sapiens |
| Length | 547 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- hereditary hypercarotenemia and vitamin A deficiency · score 0.59
- carotenoid measurement · score 0.32
- serum metabolite measurement · score 0.29
- beta-carotene measurement · score 0.24
- lutein measurement · score 0.23
- Myopia · score 0.23
- age at onset · score 0.23
- bilirubin measurement · score 0.22
- serum gamma-glutamyl transferase measurement · score 0.22
- lung adenocarcinoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HAY6-F1 | alphafold | PREDICTED | 89.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HAY6.
Amino-acid sequence (547 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BCO1?
The strongest Open Targets associations for BCO1 are hereditary hypercarotenemia and vitamin A deficiency, carotenoid measurement, serum metabolite measurement, beta-carotene measurement and lutein measurement.
How long is the BCO1 protein?
The Homo sapiens BCO1 protein (UniProt Q9HAY6) is 547 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HAY6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HAY6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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