About Transient receptor potential cation channel subfamily V member 4
Transient receptor potential cation channel subfamily V member 4 (TRPV4) is a protein
from Homo sapiens identified by UniProt accession
Q9HBA0, 871 residues long.
MolForge cross-references it against 2 known binders and
514 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (514)
Diseases linked to this target (Open Targets).
- metatropic dysplasia · score 0.84
- spondylometaphyseal dysplasia, Kozlowski type · score 0.83
- Charcot-Marie-Tooth disease axonal type 2C · score 0.80
- Autosomal dominant Charcot-Marie-Tooth disease type 2C · score 0.77
- neuronopathy, distal hereditary motor, autosomal dominant 8 · score 0.75
- familial digital arthropathy-brachydactyly · score 0.73
- autosomal dominant brachyolmia · score 0.71
- Scapuloperoneal spinal muscular atrophy · score 0.71
- spondyloepimetaphyseal dysplasia, Maroteaux type · score 0.70
- parastremmatic dwarfism · score 0.67
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9HBA0.
Amino-acid sequence (871 residues)
MADSSEGPRA GPGEVAELPG DESGTPGGEA FPLSSLANLF EGEDGSLSPS PADASRPAGP GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHSSDN KRWRKKIIEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL PFLLTHKKRL TDEEFREPST GKTCLPKALL NLSNGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGQT ALHIAIERRC KHYVELLVAQ GADVHAQARG RFFQPKDEGG YFYFGELPLS LAACTNQPHI VNYLTENPHK KADMRRQDSR GNTVLHALVA IADNTRENTK FVTKMYDLLL LKCARLFPDS NLEAVLNNDG LSPLMMAAKT GKIGIFQHII RREVTDEDTR HLSRKFKDWA YGPVYSSLYD LSSLDTCGEE ASVLEILVYN SKIENRHEML AVEPINELLR DKWRKFGAVS FYINVVSYLC AMVIFTLTAY YQPLEGTPPY PYRTTVDYLR LAGEVITLFT GVLFFFTNIK DLFMKKCPGV NSLFIDGSFQ LLYFIYSVLV IVSAALYLAG IEAYLAVMVF ALVLGWMNAL YFTRGLKLTG TYSIMIQKIL FKDLFRFLLV YLLFMIGYAS ALVSLLNPCA NMKVCNEDQT NCTVPTYPSC RDSETFSTFL LDLFKLTIGM GDLEMLSSTK YPVVFIILLV TYIILTFVLL LNMLIALMGE TVGQVSKESK HIWKLQWATT ILDIERSFPV FLRKAFRSGE MVTVGKSSDG TPDRRWCFRV DEVNWSHWNQ NLGIINEDPG KNETYQYYGF SHTVGRLRRD RWSSVVPRVV ELNKNSNPDE VVVPLDSMGN PRCDGHQQGY PRKWRTDDAP L
Explore Transient receptor potential cation channel subfamily V member 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets