POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)
Homo sapiens — UniProt Q9HBE1
Data last refreshed: (UniProt release unknown)
Key facts
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) is a protein from Homo sapiens identified by UniProt accession Q9HBE1, 687 residues long. MolForge cross-references it against 0 known binders and 312 disease associations.
- UniProt accession: Q9HBE1; gene symbol PATZ1.
- Organism: Homo sapiens.
- Length: 687 amino acids.
- Top disease associations (Open Targets): colorectal adenocarcinoma, Endometrial Endometrioid Adenocarcinoma and skin squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | POZ-, AT hook-, and zinc finger-containing protein 1 |
|---|---|
| UniProt accession | Q9HBE1 |
| Gene | PATZ1 |
| Organism | Homo sapiens |
| Length | 687 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (312)
Diseases linked to this target (Open Targets).
- colorectal adenocarcinoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- skin squamous cell carcinoma · score 0.37
- non-small cell lung carcinoma · score 0.30
- lung adenocarcinoma · score 0.29
- hepatocellular carcinoma · score 0.29
- thyroid carcinoma · score 0.28
- melanoma · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- lung carcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBE1-F1 | alphafold | PREDICTED | 59.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBE1.
Amino-acid sequence (687 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PATZ1?
The strongest Open Targets associations for PATZ1 are colorectal adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, skin squamous cell carcinoma, non-small cell lung carcinoma and lung adenocarcinoma.
How long is the PATZ1 protein?
The Homo sapiens PATZ1 protein (UniProt Q9HBE1) is 687 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBE1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBE1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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