Interleukin-21 (IL21)
Homo sapiens — UniProt Q9HBE4
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-21 (IL21) is a protein from Homo sapiens identified by UniProt accession Q9HBE4, 162 residues long. MolForge cross-references it against 0 known binders and 423 disease associations.
- UniProt accession: Q9HBE4; gene symbol IL21.
- Organism: Homo sapiens.
- Length: 162 amino acids.
- Top disease associations (Open Targets): Autosomal recessive early-onset inflammatory bowel disease, common variable immunodeficiency and primary biliary cirrhosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-21 |
|---|---|
| UniProt accession | Q9HBE4 |
| Gene | IL21 |
| Organism | Homo sapiens |
| Length | 162 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (423)
Diseases linked to this target (Open Targets).
- Autosomal recessive early-onset inflammatory bowel disease · score 0.57
- common variable immunodeficiency · score 0.42
- primary biliary cirrhosis · score 0.36
- neurodegenerative disease · score 0.33
- eosinophil count · score 0.31
- celiac disease · score 0.29
- psoriasis · score 0.27
- type 1 diabetes mellitus · score 0.27
- autoimmune disease · score 0.24
- hypothyroidism · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBE4-F1 | alphafold | PREDICTED | 83.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBE4.
Amino-acid sequence (162 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL21?
The strongest Open Targets associations for IL21 are Autosomal recessive early-onset inflammatory bowel disease, common variable immunodeficiency, primary biliary cirrhosis, neurodegenerative disease and eosinophil count.
How long is the IL21 protein?
The Homo sapiens IL21 protein (UniProt Q9HBE4) is 162 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBE4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBE4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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