Interleukin-21 receptor (IL21R)
Homo sapiens — UniProt Q9HBE5
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-21 receptor (IL21R) is a protein from Homo sapiens identified by UniProt accession Q9HBE5, 538 residues long. MolForge cross-references it against 0 known binders and 538 disease associations.
- UniProt accession: Q9HBE5; gene symbol IL21R.
- Organism: Homo sapiens.
- Length: 538 amino acids.
- Top disease associations (Open Targets): Cryptosporidiosis - chronic cholangitis - liver disease, cryptosporidiosis-chronic cholangitis-liver disease syndrome and combined immunodeficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-21 receptor |
|---|---|
| UniProt accession | Q9HBE5 |
| Gene | IL21R |
| Organism | Homo sapiens |
| Length | 538 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (538)
Diseases linked to this target (Open Targets).
- Cryptosporidiosis - chronic cholangitis - liver disease · score 0.73
- cryptosporidiosis-chronic cholangitis-liver disease syndrome · score 0.71
- combined immunodeficiency · score 0.37
- Combined immunodeficiency · score 0.37
- Omenn syndrome · score 0.37
- immunodeficiency disease · score 0.37
- primary biliary cirrhosis · score 0.35
- eosinophil count · score 0.34
- asthma · score 0.32
- Chronic mucocutaneous candidosis · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBE5-F1 | alphafold | PREDICTED | 64.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBE5.
Amino-acid sequence (538 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL21R?
The strongest Open Targets associations for IL21R are Cryptosporidiosis - chronic cholangitis - liver disease, cryptosporidiosis-chronic cholangitis-liver disease syndrome, combined immunodeficiency, Combined immunodeficiency and Omenn syndrome.
How long is the IL21R protein?
The Homo sapiens IL21R protein (UniProt Q9HBE5) is 538 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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