Zinc finger FYVE domain-containing protein 1 (ZFYVE1)
Homo sapiens — UniProt Q9HBF4
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger FYVE domain-containing protein 1 (ZFYVE1) is a protein from Homo sapiens identified by UniProt accession Q9HBF4, 777 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q9HBF4; gene symbol ZFYVE1.
- Organism: Homo sapiens.
- Length: 777 amino acids.
- Top disease associations (Open Targets): erythrocyte count, Red cell distribution width and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger FYVE domain-containing protein 1 |
|---|---|
| UniProt accession | Q9HBF4 |
| Gene | ZFYVE1 |
| Organism | Homo sapiens |
| Length | 777 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.37
- Red cell distribution width · score 0.31
- mean corpuscular hemoglobin concentration · score 0.28
- red blood cell density measurement · score 0.28
- eosinophil count · score 0.26
- age at menopause · score 0.25
- sex hormone-binding globulin measurement · score 0.24
- mean corpuscular hemoglobin · score 0.21
- body weight · score 0.20
- hip circumference · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBF4-F1 | alphafold | PREDICTED | 76.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBF4.
Amino-acid sequence (777 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZFYVE1?
The strongest Open Targets associations for ZFYVE1 are erythrocyte count, Red cell distribution width, mean corpuscular hemoglobin concentration, red blood cell density measurement and eosinophil count.
How long is the ZFYVE1 protein?
The Homo sapiens ZFYVE1 protein (UniProt Q9HBF4) is 777 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBF4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBF4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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