V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4)

About V-type proton ATPase 116 kDa subunit a 4

V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4) is a protein from Homo sapiens identified by UniProt accession Q9HBG4, 840 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	V-type proton ATPase 116 kDa subunit a 4
UniProt accession	Q9HBG4
Gene	ATP6V0A4
Organism	Homo sapiens
Length	840 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

renal tubular acidosis, distal, 3, with or without sensorineural hearing loss · score 0.78
autosomal recessive distal renal tubular acidosis · score 0.64
genetic disorder · score 0.47
distal renal tubular acidosis · score 0.46
high density lipoprotein cholesterol measurement · score 0.31
sleep duration · score 0.31
sensorineural hearing loss · score 0.27
Sensorineural hearing impairment · score 0.27
breast adenocarcinoma · score 0.21
age-related hearing impairment · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HBG4-F1	alphafold	PREDICTED	82.97	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBG4.

Amino-acid sequence (840 residues)

MVSVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK FVNEVRRCES LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL EKLEGELQEA NQNQQALKQS FLELTELKYL LKKTQDFFET ETNLADDFFT EDTSGLLELK AVPAYMTGKL GFIAGVINRE RMASFERLLW RICRGNVYLK FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD GFRATVYPCP EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM APIMTTVQSK TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT FPFLFAVMFG DCGHGTVMLL AALWMILNER RLLSQKTDNE IWNTFFHGRY LILLMGIFSI YTGLIYNDCF SKSLNIFGSS WSVQPMFRNG TWNTHVMEES LYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK MKMSVILGIV QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS VPWMLLIKPF ILRASHRKSQ LQASRIQEDA TENIEGDSSS PSSRSGQRTS ADTHGALDDH GEEFNFGDVF VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWT MVMNSGLQTR GWGGIVGVFI IFAVFAVLTV AILLIMEGLS AFLHALRLHW VEFQNKFYVG DGYKFSPFSF KHILDGTAEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards