Intraflagellar transport protein 122 homolog (IFT122)
Homo sapiens — UniProt Q9HBG6
Data last refreshed: (UniProt release unknown)
Key facts
Intraflagellar transport protein 122 homolog (IFT122) is a protein from Homo sapiens identified by UniProt accession Q9HBG6, 1241 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q9HBG6; gene symbol IFT122.
- Organism: Homo sapiens.
- Length: 1241 amino acids.
- Top disease associations (Open Targets): cranioectodermal dysplasia, Cone rod dystrophy and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Intraflagellar transport protein 122 homolog |
|---|---|
| UniProt accession | Q9HBG6 |
| Gene | IFT122 |
| Organism | Homo sapiens |
| Length | 1241 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- cranioectodermal dysplasia · score 0.82
- Cone rod dystrophy · score 0.27
- genetic disorder · score 0.19
- connective tissue disease · score 0.18
- low density lipoprotein cholesterol measurement · score 0.15
- BMI-adjusted waist-hip ratio · score 0.15
- Microcephaly · score 0.11
- serum gamma-glutamyl transferase measurement · score 0.09
- Syndactyly type 2 · score 0.07
- systemic lupus erythematosus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBG6-F1 | alphafold | PREDICTED | 82.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBG6.
Amino-acid sequence (1241 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFT122?
The strongest Open Targets associations for IFT122 are cranioectodermal dysplasia, Cone rod dystrophy, genetic disorder, connective tissue disease and low density lipoprotein cholesterol measurement.
How long is the IFT122 protein?
The Homo sapiens IFT122 protein (UniProt Q9HBG6) is 1241 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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