Tensin-1 (TNS1)
Homo sapiens — UniProt Q9HBL0
Data last refreshed: (UniProt release unknown)
Key facts
Tensin-1 (TNS1) is a protein from Homo sapiens identified by UniProt accession Q9HBL0, 1839 residues long. MolForge cross-references it against 0 known binders and 285 disease associations.
- UniProt accession: Q9HBL0; gene symbol TNS1.
- Organism: Homo sapiens.
- Length: 1839 amino acids.
- Top disease associations (Open Targets): reticulocyte count, forced expiratory volume and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tensin-1 |
|---|---|
| UniProt accession | Q9HBL0 |
| Gene | TNS1 |
| Organism | Homo sapiens |
| Length | 1839 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (285)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.45
- forced expiratory volume · score 0.42
- type 2 diabetes mellitus · score 0.42
- chronic obstructive pulmonary disease · score 0.42
- systolic blood pressure · score 0.41
- vital capacity · score 0.41
- erythrocyte count · score 0.41
- reticulocyte measurement · score 0.40
- intraocular pressure measurement · score 0.40
- diastolic blood pressure · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBL0-F1 | alphafold | PREDICTED | 52.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBL0.
Amino-acid sequence (1839 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNS1?
The strongest Open Targets associations for TNS1 are reticulocyte count, forced expiratory volume, type 2 diabetes mellitus, chronic obstructive pulmonary disease and systolic blood pressure.
How long is the TNS1 protein?
The Homo sapiens TNS1 protein (UniProt Q9HBL0) is 1839 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBL0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBL0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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