Leucine-rich repeat and transmembrane domain-containing protein 1 (LRTM1)
Homo sapiens — UniProt Q9HBL6
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and transmembrane domain-containing protein 1 (LRTM1) is a protein from Homo sapiens identified by UniProt accession Q9HBL6, 345 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q9HBL6; gene symbol LRTM1.
- Organism: Homo sapiens.
- Length: 345 amino acids.
- Top disease associations (Open Targets): body height, PHF-tau measurement and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and transmembrane domain-containing protein 1 |
|---|---|
| UniProt accession | Q9HBL6 |
| Gene | LRTM1 |
| Organism | Homo sapiens |
| Length | 345 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- body height · score 0.27
- PHF-tau measurement · score 0.27
- FEV/FVC ratio · score 0.20
- peak expiratory flow · score 0.14
- chronic obstructive pulmonary disease · score 0.14
- type 2 diabetes mellitus · score 0.13
- neurofibrillary tangles measurement · score 0.12
- vital capacity · score 0.12
- facial morphology measurement · score 0.08
- white matter microstructure measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBL6-F1 | alphafold | PREDICTED | 81.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBL6.
Amino-acid sequence (345 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRTM1?
The strongest Open Targets associations for LRTM1 are body height, PHF-tau measurement, FEV/FVC ratio, peak expiratory flow and chronic obstructive pulmonary disease.
How long is the LRTM1 protein?
The Homo sapiens LRTM1 protein (UniProt Q9HBL6) is 345 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBL6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBL6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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