Kinetochore protein Spc25 (SPC25)
Homo sapiens — UniProt Q9HBM1
Data last refreshed: (UniProt release unknown)
Key facts
Kinetochore protein Spc25 (SPC25) is a protein from Homo sapiens identified by UniProt accession Q9HBM1, 224 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.
- UniProt accession: Q9HBM1; gene symbol SPC25.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, fasting blood glucose measurement and HbA1c measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kinetochore protein Spc25 |
|---|---|
| UniProt accession | Q9HBM1 |
| Gene | SPC25 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (96)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- fasting blood glucose measurement · score 0.47
- HbA1c measurement · score 0.46
- glucose measurement · score 0.46
- BMI-adjusted fasting blood glucose measurement · score 0.42
- monocyte count · score 0.42
- body height · score 0.42
- leukocyte count · score 0.40
- neutrophil count · score 0.40
- pulse pressure measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBM1-F1 | alphafold | PREDICTED | 91.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBM1.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPC25?
The strongest Open Targets associations for SPC25 are neurodegenerative disease, fasting blood glucose measurement, HbA1c measurement, glucose measurement and BMI-adjusted fasting blood glucose measurement.
How long is the SPC25 protein?
The Homo sapiens SPC25 protein (UniProt Q9HBM1) is 224 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBM1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBM1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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