Homeobox protein BarH-like 1 (BARX1)
Homo sapiens — UniProt Q9HBU1
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein BarH-like 1 (BARX1) is a protein from Homo sapiens identified by UniProt accession Q9HBU1, 254 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q9HBU1; gene symbol BARX1.
- Organism: Homo sapiens.
- Length: 254 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, heel bone mineral density and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein BarH-like 1 |
|---|---|
| UniProt accession | Q9HBU1 |
| Gene | BARX1 |
| Organism | Homo sapiens |
| Length | 254 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.47
- heel bone mineral density · score 0.47
- neurodegenerative disease · score 0.46
- waist-hip ratio · score 0.46
- bone quantitative ultrasound measurement · score 0.36
- infantile hypertrophic pyloric stenosis · score 0.32
- diaphragmatic hernia · score 0.30
- esophageal adenocarcinoma · score 0.27
- Barrett's esophagus · score 0.26
- body mass index · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBU1-F1 | alphafold | PREDICTED | 63.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBU1.
Amino-acid sequence (254 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BARX1?
The strongest Open Targets associations for BARX1 are BMI-adjusted waist-hip ratio, heel bone mineral density, neurodegenerative disease, waist-hip ratio and bone quantitative ultrasound measurement.
How long is the BARX1 protein?
The Homo sapiens BARX1 protein (UniProt Q9HBU1) is 254 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBU1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBU1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.