Popeye domain-containing protein 2 (POPDC2)
Homo sapiens — UniProt Q9HBU9
Data last refreshed: (UniProt release unknown)
Key facts
Popeye domain-containing protein 2 (POPDC2) is a protein from Homo sapiens identified by UniProt accession Q9HBU9, 364 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9HBU9; gene symbol POPDC2.
- Organism: Homo sapiens.
- Length: 364 amino acids.
- Top disease associations (Open Targets): blood protein measurement, hypertrophic cardiomyopathy and Arrhythmogenic right ventricular dysplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Popeye domain-containing protein 2 |
|---|---|
| UniProt accession | Q9HBU9 |
| Gene | POPDC2 |
| Organism | Homo sapiens |
| Length | 364 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.25
- hypertrophic cardiomyopathy · score 0.08
- Arrhythmogenic right ventricular dysplasia · score 0.07
- Romano-Ward syndrome · score 0.07
- Familial progressive cardiac conduction defect · score 0.07
- Brugada syndrome · score 0.07
- dilated cardiomyopathy · score 0.06
- Familial short QT syndrome · score 0.06
- familial atrial fibrillation · score 0.06
- familial sick sinus syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBU9-F1 | alphafold | PREDICTED | 75.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBU9.
Amino-acid sequence (364 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POPDC2?
The strongest Open Targets associations for POPDC2 are blood protein measurement, hypertrophic cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Romano-Ward syndrome and Familial progressive cardiac conduction defect.
How long is the POPDC2 protein?
The Homo sapiens POPDC2 protein (UniProt Q9HBU9) is 364 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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