Serine/threonine-protein kinase Sgk2 (SGK2)
Homo sapiens — UniProt Q9HBY8
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase Sgk2 (SGK2) is a protein from Homo sapiens identified by UniProt accession Q9HBY8, 367 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9HBY8; gene symbol SGK2.
- Organism: Homo sapiens.
- Length: 367 amino acids.
- Top disease associations (Open Targets): colorectal cancer, neurodegenerative disease and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase Sgk2 |
|---|---|
| UniProt accession | Q9HBY8 |
| Gene | SGK2 |
| Organism | Homo sapiens |
| Length | 367 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- colorectal cancer · score 0.26
- neurodegenerative disease · score 0.26
- neuroinflammatory disorder · score 0.25
- leukocyte count · score 0.23
- monocyte count · score 0.20
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.12
- myeloid white cell count · score 0.08
- body fat percentage · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HBY8-F1 | alphafold | PREDICTED | 86.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HBY8.
Amino-acid sequence (367 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SGK2?
The strongest Open Targets associations for SGK2 are colorectal cancer, neurodegenerative disease, neuroinflammatory disorder, leukocyte count and monocyte count.
How long is the SGK2 protein?
The Homo sapiens SGK2 protein (UniProt Q9HBY8) is 367 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HBY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HBY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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