Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)
Homo sapiens — UniProt Q9HCC0
Data last refreshed: (UniProt release unknown)
Key facts
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) is a protein from Homo sapiens identified by UniProt accession Q9HCC0, 563 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q9HCC0; gene symbol MCCC2.
- Organism: Homo sapiens.
- Length: 563 amino acids.
- Top disease associations (Open Targets): 3-methylcrotonyl-CoA carboxylase 2 deficiency, Isolated 3-methylcrotonyl-CoA carboxylase deficiency and 3-methylcrotonyl-CoA carboxylase deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
|---|---|
| UniProt accession | Q9HCC0 |
| Gene | MCCC2 |
| Organism | Homo sapiens |
| Length | 563 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- 3-methylcrotonyl-CoA carboxylase 2 deficiency · score 0.84
- Isolated 3-methylcrotonyl-CoA carboxylase deficiency · score 0.70
- 3-methylcrotonyl-CoA carboxylase deficiency · score 0.68
- genetic disorder · score 0.45
- autism spectrum disorder · score 0.33
- Alzheimer disease · score 0.25
- Parkinson disease · score 0.25
- neurodegenerative disease · score 0.25
- lysosomal storage disease · score 0.25
- multiple sclerosis · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCC0-F1 | alphafold | PREDICTED | 94.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCC0.
Amino-acid sequence (563 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MCCC2?
The strongest Open Targets associations for MCCC2 are 3-methylcrotonyl-CoA carboxylase 2 deficiency, Isolated 3-methylcrotonyl-CoA carboxylase deficiency, 3-methylcrotonyl-CoA carboxylase deficiency, genetic disorder and autism spectrum disorder.
How long is the MCCC2 protein?
The Homo sapiens MCCC2 protein (UniProt Q9HCC0) is 563 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCC0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCC0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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