Transcription factor HES-4 (HES4)
Homo sapiens — UniProt Q9HCC6
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor HES-4 (HES4) is a protein from Homo sapiens identified by UniProt accession Q9HCC6, 221 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q9HCC6; gene symbol HES4.
- Organism: Homo sapiens.
- Length: 221 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor HES-4 |
|---|---|
| UniProt accession | Q9HCC6 |
| Gene | HES4 |
| Organism | Homo sapiens |
| Length | 221 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- Parkinson disease · score 0.33
- Alzheimer disease · score 0.33
- multiple sclerosis · score 0.33
- lysosomal storage disease · score 0.33
- high density lipoprotein cholesterol measurement · score 0.29
- apolipoprotein A 1 measurement · score 0.28
- alcohol consumption measurement · score 0.21
- cortical surface area measurement · score 0.17
- total blood protein measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCC6-F1 | alphafold | PREDICTED | 72.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCC6.
Amino-acid sequence (221 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HES4?
The strongest Open Targets associations for HES4 are neurodegenerative disease, Parkinson disease, Alzheimer disease, multiple sclerosis and lysosomal storage disease.
How long is the HES4 protein?
The Homo sapiens HES4 protein (UniProt Q9HCC6) is 221 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCC6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCC6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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