Lateral signaling target protein 2 homolog (ZFYVE28)
Homo sapiens — UniProt Q9HCC9
Data last refreshed: (UniProt release unknown)
Key facts
Lateral signaling target protein 2 homolog (ZFYVE28) is a protein from Homo sapiens identified by UniProt accession Q9HCC9, 887 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9HCC9; gene symbol ZFYVE28.
- Organism: Homo sapiens.
- Length: 887 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, YKL40 measurement and inflammatory biomarker measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lateral signaling target protein 2 homolog |
|---|---|
| UniProt accession | Q9HCC9 |
| Gene | ZFYVE28 |
| Organism | Homo sapiens |
| Length | 887 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- YKL40 measurement · score 0.33
- inflammatory biomarker measurement · score 0.33
- protein measurement · score 0.18
- genetic disorder · score 0.12
- Insulin resistance · score 0.08
- hemochromatosis type 5 · score 0.05
- FTH1-related iron overload · score 0.05
- monocyte count · score 0.04
- hereditary hyperferritinemia with congenital cataracts · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCC9-F1 | alphafold | PREDICTED | 60.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCC9.
Amino-acid sequence (887 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZFYVE28?
The strongest Open Targets associations for ZFYVE28 are neurodegenerative disease, YKL40 measurement, inflammatory biomarker measurement, protein measurement and genetic disorder.
How long is the ZFYVE28 protein?
The Homo sapiens ZFYVE28 protein (UniProt Q9HCC9) is 887 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCC9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCC9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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