N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (METTL14)
Homo sapiens — UniProt Q9HCE5
Data last refreshed: (UniProt release unknown)
Key facts
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (METTL14) is a protein from Homo sapiens identified by UniProt accession Q9HCE5, 456 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.
- UniProt accession: Q9HCE5; gene symbol METTL14.
- Organism: Homo sapiens.
- Length: 456 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neoplasm and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 |
|---|---|
| UniProt accession | Q9HCE5 |
| Gene | METTL14 |
| Organism | Homo sapiens |
| Length | 456 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (239)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.11
- nonpapillary renal cell carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.10
- cancer · score 0.10
- renal cell carcinoma · score 0.10
- oral squamous cell carcinoma · score 0.10
- breast cancer · score 0.09
- gonorrhea · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCE5-F1 | alphafold | PREDICTED | 79.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCE5.
Amino-acid sequence (456 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL14?
The strongest Open Targets associations for METTL14 are neurodegenerative disease, neoplasm, hepatocellular carcinoma, nonpapillary renal cell carcinoma and non-small cell lung carcinoma.
How long is the METTL14 protein?
The Homo sapiens METTL14 protein (UniProt Q9HCE5) is 456 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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