Rho guanine nucleotide exchange factor 10-like protein (ARHGEF10L)
Homo sapiens — UniProt Q9HCE6
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 10-like protein (ARHGEF10L) is a protein from Homo sapiens identified by UniProt accession Q9HCE6, 1279 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.
- UniProt accession: Q9HCE6; gene symbol ARHGEF10L.
- Organism: Homo sapiens.
- Length: 1279 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, visual perception measurement and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 10-like protein |
|---|---|
| UniProt accession | Q9HCE6 |
| Gene | ARHGEF10L |
| Organism | Homo sapiens |
| Length | 1279 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (126)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- visual perception measurement · score 0.32
- neuroticism measurement · score 0.31
- lymphocyte count · score 0.27
- Rare genetic intellectual disability with developmental anomaly · score 0.27
- thyroid gland adenocarcinoma · score 0.22
- clear cell renal carcinoma · score 0.22
- neoplasm · score 0.19
- acute myeloid leukemia · score 0.19
- oral squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCE6-F1 | alphafold | PREDICTED | 67.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCE6.
Amino-acid sequence (1279 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF10L?
The strongest Open Targets associations for ARHGEF10L are neurodegenerative disease, visual perception measurement, neuroticism measurement, lymphocyte count and Rare genetic intellectual disability with developmental anomaly.
How long is the ARHGEF10L protein?
The Homo sapiens ARHGEF10L protein (UniProt Q9HCE6) is 1279 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCE6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCE6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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