E3 ubiquitin-protein ligase SMURF1 (SMURF1)
Homo sapiens — UniProt Q9HCE7
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase SMURF1 (SMURF1) is a protein from Homo sapiens identified by UniProt accession Q9HCE7, 757 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.
- UniProt accession: Q9HCE7; gene symbol SMURF1.
- Organism: Homo sapiens.
- Length: 757 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, ulcerative colitis and inflammatory bowel disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase SMURF1 |
|---|---|
| UniProt accession | Q9HCE7 |
| Gene | SMURF1 |
| Organism | Homo sapiens |
| Length | 757 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (173)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.37
- ulcerative colitis · score 0.34
- inflammatory bowel disease · score 0.32
- mean corpuscular hemoglobin · score 0.31
- body height · score 0.26
- mean corpuscular hemoglobin concentration · score 0.24
- eosinophil count · score 0.24
- eosinophil percentage of leukocytes · score 0.20
- endometrial cancer · score 0.18
- self reported educational attainment · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCE7-F1 | alphafold | PREDICTED | 73.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCE7.
Amino-acid sequence (757 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMURF1?
The strongest Open Targets associations for SMURF1 are mean corpuscular volume, ulcerative colitis, inflammatory bowel disease, mean corpuscular hemoglobin and body height.
How long is the SMURF1 protein?
The Homo sapiens SMURF1 protein (UniProt Q9HCE7) is 757 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCE7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCE7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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