About DBF4-type zinc finger-containing protein 2
DBF4-type zinc finger-containing protein 2 (ZDBF2) is a protein
from Homo sapiens identified by UniProt accession
Q9HCK1, 2354 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | DBF4-type zinc finger-containing protein 2 |
|---|
| UniProt accession | Q9HCK1 |
|---|
| Gene | ZDBF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 2354 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- body mass index · score 0.41
- age at menarche · score 0.34
- neurodegenerative disease · score 0.26
- nasopalpebral lipoma-coloboma syndrome · score 0.12
- breast ductal adenocarcinoma · score 0.11
- tooth agenesis · score 0.09
- transient myeloproliferative syndrome · score 0.05
- health study participation · score 0.05
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
- reticular dysgenesis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCK1-F1 | alphafold | PREDICTED | 34.57 | — |
Amino-acid sequence (2354 residues)
MQKRQGYCSY CRVQYNNLEQ HLFSAQHRSL TRQSRRQICT SSLMERFLQD VLQHHPYHCQ ESSSTQDETH VNTGSSSEVV HLDDAFSEEE EEDEDKVEDE DATEERPSEV SEPIEELHSR PHKSQEGTQE VSVRPSVIQK LEKGQQQPLE FVHKIGASVR KCNLVDIGQA TNNRSNLVRP PVICNAPASC LPESSNDRPV TANTTSLPPA AHLDSVSKCD PNKVEKYLEQ PDGASRNPVP SSHVETTSFS YQKHKESNRK SLRMNSDKLV LWKDVKSQGK TLSAGLKFHE RMGTKGSLRV KSPSKLAVNP NKTDMPSNKG IFEDTIAKNH EEFFSNMDCT QEEKHLVFNK TAFWEQKCSV SSEMKFDCIS LQSASDQPQE TAQDLSLWKE EQIDQEDNYE SRGSEMSFDC SSSFHSLTDQ SKVSAKEVNL SKEVRTDVQY KNNKSYVSKI SSDCDDILHL VTNQSQMIVK EISLQNARHI SLVDQSYESS SSETNFDCDA SPQSTSDYPQ QSVTEVNLPK EVHIGLVDKN YGSSSSEVSA DSVFPLQSVV DRPPVAVTET KLRKKAHTSL VDNYGSSCSE TSFDCDVSLE SVVDHPQLTV KGRNLKGRQV HLKHKKRKPS SAKAHLDCDV SLGTVADESQ RAVEKINLLK EKNADLMDMN CESHGPEMGF QADAQLADQS QVAEIERQKV DVDLENKSVQ SSRSSLSSDS PASLYHSAHD EPQEALDEVN LKELNIDMEV RSYDCSSSEL TFDSDPPLLS VTEQSHLDAE GKERHIDLED ESCESDSSEI TFDSDIPLYS VIDQPEVAVY EEETVDLESK SNESCVSEIT FDSDIPLHSG NDHPEVAVKE VIQKEEYIHL ERKNDEPSGS EISSDSHAPL HSVTNSPEVA VKKLNPQKEE QVHLENKENE PIDSEVSLDY NIIFHSVTGR SEDPIKEISL HTKEHMYLEN KSVFETSLDS DVPLQAATHK PEVIVKETWL QREKHAEFQG RSTEFSGSKT SLDSGVPHYS VTEPQVAVNK INRKKQYVLE NKNDKCSGSE IILDSNVPPQ SMTDQPQLAF LKEKHVNLKD KNSKSGDSKI TFDSEQLQEA VKKIDQWKEE VIGLKNKINE PSTYKLIHHP DVSVQSVADQ PKVAIKHVNL GNENHMYLEV KNSQYSCSEM NLDSGFLGQS IVNRPQITIL EQEHIELEGK HNQCCGSEVS FDSDDPLQSV ADRLRETVKE ISLWKDEEVD TEDRRNEAKG FEIMYDSDVL QPVAGQPEEV VKEVSLWKEH VDLENKIVKP TDSRINFDSH EPLQSVTNKI PGANKEINLL REEHVCLDDK GYVPSDSEII YVSNIPLQSV IKQPHILEEE HASLEDKSSN SYSPEESSDS NDSFQAAADE LQKPVKEINL WKEDHIYLED KSYKLGDFDV SYASHIPVQF VTDQSSVPVK EINLQKKDHN DLENKNCEVC GSEIKCHSCV HLQSEVDQPQ VSYKEADLQK EEHVVMEEKT DQPSDSEMMY DSDVPFQIVV NQFPGSVKET HLPKVVLVDL VPGDSDYEVI SDDIPLQLVT DPPQLTVKDI SCINTECIDI EDKSCDFFGS EVRCNCKAST PSMTNQCKET FKIINRKKDY IILGEPSCQS CGSEMNFNVD ASDQSMTYES QGPDEKMVKY IDSEDKSCGY NGSKGKFNLE DTSHRTTHRL QKAHKEASLR KDPRNAGLKG KSCQSSASAV DFGASSKSAL HRRADKKKRS KLKHRDLEVS CEPDGFEMNF QCAPPLPSDT DQPQETVKKR HPCKKVSSDL KEKNHDSQSS SVLKVDSVRN LKKAKDVIED NPDEPVLEAL PHVPPSFVGK TWSQIMREDD IKINALVKEF REGRFHCYFD DDCETKKVSS KGKKKVTWAD LQGKEDTAPT QAVSESDDIV CGISDIDDLS VALDKPCHRH PPAERPPKQK GRVASQCQTA KISHSTQTSC KNYPVMKRKI IRQEEDPPKS KCSRLQDDRK TKKKVKIGTV EFPASCTKVL KPMQPKALVC VLSSLNIKLK EGEGLPFPKM RHHSWDNDIR FICKYKRNIF DYYEPLIKQI VISPPLSVIV PEFERRNWVK IHFNRSNQNS SAGDNDADGQ GSASAPLMAV PARYGFNSHQ GTSDSSLFLE ESKVLHAREL PKKRNFQLTF LNHDVVKISP KSVRNKLLES QSKKKIHGKR VTTSSNKLGF PKKVYKPIIL QQKPRKASEK QSIWIRTKPS DIIRKYISKY SVFLRHRYQS RSAFLGRYLK KKKSVVSRLK KAKRTAKVLL NSSVPPAGAE ELSSAMANPP PKRPVRASCR VARRRKKTDE SYHGRQKGPS TPVRAYDLRS SSCLQQRERM MTRLANKLRG NEVK
Explore DBF4-type zinc finger-containing protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets