Protocadherin-18 (PCDH18)
Homo sapiens — UniProt Q9HCL0
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin-18 (PCDH18) is a protein from Homo sapiens identified by UniProt accession Q9HCL0, 1135 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q9HCL0; gene symbol PCDH18.
- Organism: Homo sapiens.
- Length: 1135 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, hypertension and cardiovascular disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin-18 |
|---|---|
| UniProt accession | Q9HCL0 |
| Gene | PCDH18 |
| Organism | Homo sapiens |
| Length | 1135 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.47
- hypertension · score 0.45
- cardiovascular disease · score 0.39
- Beta blocking agent use measurement · score 0.39
- blood pressure · score 0.32
- age at diagnosis · score 0.30
- essential hypertension · score 0.30
- body height · score 0.30
- Agents acting on the renin-angiotensin system use measurement · score 0.28
- mean platelet volume · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCL0-F1 | alphafold | PREDICTED | 68.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCL0.
Amino-acid sequence (1135 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDH18?
The strongest Open Targets associations for PCDH18 are systolic blood pressure, hypertension, cardiovascular disease, Beta blocking agent use measurement and blood pressure.
How long is the PCDH18 protein?
The Homo sapiens PCDH18 protein (UniProt Q9HCL0) is 1135 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCL0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCL0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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