Platelet glycoprotein VI (GP6)
Homo sapiens — UniProt Q9HCN6
Data last refreshed: (UniProt release unknown)
Key facts
Platelet glycoprotein VI (GP6) is a protein from Homo sapiens identified by UniProt accession Q9HCN6, 339 residues long. MolForge cross-references it against 7 known binders and 267 disease associations.
- UniProt accession: Q9HCN6; gene symbol GP6.
- Organism: Homo sapiens.
- Length: 339 amino acids.
- Top disease associations (Open Targets): platelet-type bleeding disorder 11, Bleeding diathesis due to glycoprotein VI deficiency and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Platelet glycoprotein VI |
|---|---|
| UniProt accession | Q9HCN6 |
| Gene | GP6 |
| Organism | Homo sapiens |
| Length | 339 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (267)
Diseases linked to this target (Open Targets).
- platelet-type bleeding disorder 11 · score 0.72
- Bleeding diathesis due to glycoprotein VI deficiency · score 0.68
- reticulocyte count · score 0.39
- mean platelet volume · score 0.39
- platelet component distribution width · score 0.37
- platelet count · score 0.36
- platelet aggregation · score 0.32
- reticulocyte measurement · score 0.31
- blood protein measurement · score 0.31
- mitochondrial DNA measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCN6-F1 | alphafold | PREDICTED | 76.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCN6.
Amino-acid sequence (339 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GP6?
The strongest Open Targets associations for GP6 are platelet-type bleeding disorder 11, Bleeding diathesis due to glycoprotein VI deficiency, reticulocyte count, mean platelet volume and platelet component distribution width.
How long is the GP6 protein?
The Homo sapiens GP6 protein (UniProt Q9HCN6) is 339 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCN6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCN6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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