Transcription factor 7-like 1 (TCF7L1)
Homo sapiens — UniProt Q9HCS4
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor 7-like 1 (TCF7L1) is a protein from Homo sapiens identified by UniProt accession Q9HCS4, 588 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q9HCS4; gene symbol TCF7L1.
- Organism: Homo sapiens.
- Length: 588 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, aspartate aminotransferase measurement and total blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor 7-like 1 |
|---|---|
| UniProt accession | Q9HCS4 |
| Gene | TCF7L1 |
| Organism | Homo sapiens |
| Length | 588 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- aspartate aminotransferase measurement · score 0.42
- total blood protein measurement · score 0.36
- erythrocyte count · score 0.34
- refractive error measurement · score 0.31
- pulse pressure measurement · score 0.31
- bone density · score 0.31
- PHF-tau measurement · score 0.30
- heel bone mineral density · score 0.30
- platelet count · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCS4-F1 | alphafold | PREDICTED | 51.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCS4.
Amino-acid sequence (588 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TCF7L1?
The strongest Open Targets associations for TCF7L1 are neurodegenerative disease, aspartate aminotransferase measurement, total blood protein measurement, erythrocyte count and refractive error measurement.
How long is the TCF7L1 protein?
The Homo sapiens TCF7L1 protein (UniProt Q9HCS4) is 588 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCS4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCS4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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