Fibroblast growth factor 22 (FGF22)
Homo sapiens — UniProt Q9HCT0
Data last refreshed: (UniProt release unknown)
Key facts
Fibroblast growth factor 22 (FGF22) is a protein from Homo sapiens identified by UniProt accession Q9HCT0, 170 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q9HCT0; gene symbol FGF22.
- Organism: Homo sapiens.
- Length: 170 amino acids.
- Top disease associations (Open Targets): cancer, bone development disease and female reproductive endometrioid cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fibroblast growth factor 22 |
|---|---|
| UniProt accession | Q9HCT0 |
| Gene | FGF22 |
| Organism | Homo sapiens |
| Length | 170 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- cancer · score 0.58
- bone development disease · score 0.57
- female reproductive endometrioid cancer · score 0.46
- ovarian carcinoma · score 0.37
- head and neck squamous cell carcinoma · score 0.28
- gastric adenocarcinoma · score 0.15
- Spinal cord injury · score 0.07
- Benign familial chorea · score 0.05
- glioblastoma multiforme · score 0.03
- papilloma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCT0-F1 | alphafold | PREDICTED | 88.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCT0.
Amino-acid sequence (170 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FGF22?
The strongest Open Targets associations for FGF22 are cancer, bone development disease, female reproductive endometrioid cancer, ovarian carcinoma and head and neck squamous cell carcinoma.
How long is the FGF22 protein?
The Homo sapiens FGF22 protein (UniProt Q9HCT0) is 170 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCT0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCT0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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