Breast cancer metastasis-suppressor 1 (BRMS1)
Homo sapiens — UniProt Q9HCU9
Data last refreshed: (UniProt release unknown)
Key facts
Breast cancer metastasis-suppressor 1 (BRMS1) is a protein from Homo sapiens identified by UniProt accession Q9HCU9, 246 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9HCU9; gene symbol BRMS1.
- Organism: Homo sapiens.
- Length: 246 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Breast cancer metastasis-suppressor 1 |
|---|---|
| UniProt accession | Q9HCU9 |
| Gene | BRMS1 |
| Organism | Homo sapiens |
| Length | 246 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- breast adenocarcinoma · score 0.24
- endometrial cancer · score 0.14
- BMI-adjusted waist-hip ratio · score 0.13
- acute myeloid leukemia · score 0.12
- waist-hip ratio · score 0.11
- non-small cell lung carcinoma · score 0.09
- hepatocellular carcinoma · score 0.09
- osteosarcoma · score 0.09
- melanoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HCU9-F1 | alphafold | PREDICTED | 78.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HCU9.
Amino-acid sequence (246 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRMS1?
The strongest Open Targets associations for BRMS1 are neurodegenerative disease, breast adenocarcinoma, endometrial cancer, BMI-adjusted waist-hip ratio and acute myeloid leukemia.
How long is the BRMS1 protein?
The Homo sapiens BRMS1 protein (UniProt Q9HCU9) is 246 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HCU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HCU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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