Junctophilin-1 (JPH1)
Homo sapiens — UniProt Q9HDC5
Data last refreshed: (UniProt release unknown)
Key facts
Junctophilin-1 (JPH1) is a protein from Homo sapiens identified by UniProt accession Q9HDC5, 661 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q9HDC5; gene symbol JPH1.
- Organism: Homo sapiens.
- Length: 661 amino acids.
- Top disease associations (Open Targets): body height, adolescent idiopathic scoliosis and pericarditis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Junctophilin-1 |
|---|---|
| UniProt accession | Q9HDC5 |
| Gene | JPH1 |
| Organism | Homo sapiens |
| Length | 661 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- body height · score 0.31
- adolescent idiopathic scoliosis · score 0.22
- pericarditis · score 0.22
- type 2 diabetes mellitus · score 0.22
- neuroimaging measurement · score 0.21
- brain volume measurement · score 0.21
- white matter microstructure measurement · score 0.20
- drug use measurement · score 0.10
- Distal myopathy, Nonaka type · score 0.05
- inclusion body myositis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HDC5-F1 | alphafold | PREDICTED | 65.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HDC5.
Amino-acid sequence (661 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with JPH1?
The strongest Open Targets associations for JPH1 are body height, adolescent idiopathic scoliosis, pericarditis, type 2 diabetes mellitus and neuroimaging measurement.
How long is the JPH1 protein?
The Homo sapiens JPH1 protein (UniProt Q9HDC5) is 661 amino acids long.
Browse: Targets: J · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HDC5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HDC5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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